Efficient in vitro delivery of Noggin siRNA enhances osteoblastogenesis

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Efficient in vitro delivery of Noggin siRNA enhances osteoblastogenesis

Several types of serious bone defects would not heal without invasive clinical intervention. One approach to such defects is to enhance the capacity of bone-formation cells. Exogenous bone morphogenetic proteins (BMP) have been utilized to positively regulate matrix mineralization and osteoblastogenesis, however, numerous adverse effects are associated with this approach. Noggin, a potent antag...

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ژورنال

عنوان ژورنال: Heliyon

سال: 2017

ISSN: 2405-8440

DOI: 10.1016/j.heliyon.2017.e00450